The GRK2 Antibody from MyBioSource.com is a Mouse Monoclonal antibody to GRK2. This antibody recognizes Human, Mouse, Rat, and Non-Human Primate antigen. The GRK2 Antibody has been validated for the following applications: ELISA, Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
Background: The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. (provided by RefSeq)Tissue specificity: Expressed in peripheral blood leukocytes